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In summary, our findings demonstrate that mtDNA mutations drive a multifaceted adaptive program encompassing bioenergetic resilience, enhanced translational capacity, and immune remodelling (Extended Data Fig

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c-Myc directly activates the genes involved in nucleotide synthesis, including thymidylate synthase for pyrimidine metabolism, inosine monophosphate dehydrogenase 1 and 2 for purine metabolism, and phosphoribosyl pyrophosphate (PRPP) synthetase 2 for the production of PRPP, which is a common precursor for purine and pyrimidine nucleotides

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Lassmann H, Brck W, Lucchinetti CF (2007) The immunopathology of multiple sclerosis: an overview