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As a key regulator of glutamate metabolism, branched-chain amino acid transaminase 2 activates system Xc-activity through ectopic expression, protecting HCC cells from ferroptosis in vitro and in vivo

*Due to regulatory changes, weight and height ranges may vary by model

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TABLE 1 Summary of SIRT1 modulators and their aging-related mechanisms in liver diseases

At this hepatocarcinogenic stage, hexosylceramide (HexCer) d18:1/16:0, d18:1/22:0, d18:1/24:0, lactosylceramide (LacCer) d18:1/24:0, sphingomyelin (SM) d18:1/16:0, 18:1/22:0, and 18:1/24:0 were significantly lower in PTEN KO than wild-type mice