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Another challenge lies in the shift from laboratory-scale synthesis to scalable good manufacturing practice (GMP)-compliant production, where achieving consistent particle characteristics, such as size, zeta potential, and drug loading, is critical [252, 418]

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This comprehensive review critically examines recent advances in targeting ferroptosis, an iron-dependent form of non-apoptotic cell death mediated through reactive oxygen species (ROS) accumulation and lipid membrane peroxidation, for therapeutic intervention in GBM