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Outside of the Mdm2 binding motif, ~70% (47 out of 66) of the single substitutions maintained low nanomolar-affinity binding ( 90 M, Supplementary Table 1)

Keep in mind that copper peptides are sensitive to pH

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However, similar to GnRH agonist, GnRH antagonist is associated with hypoestrogenic adverse effects, which require the addition of estradiol and norethindrone acetate (add-back therapy) to attenuate the hypoestrogenic effect (Schlaff et al., 2020)

Individual results vary by protocol, goal, and patient health history