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156 HickmanS.IzzyS.SenP.MorsettL.KhouryJ

Psychoneuroendocrinology 64 , 150163 (2016)

Compound Name: Tirzepatide (Dual Agonist Analog)

This assumption is reinforced by the observation that N-acetyl-L-cysteine (NAC, an antioxidant thiol and a precursor for L-cysteine, the rate-limiting amino acid in the biosynthesis of glutathione [14, 17, 112]) imposes a reducing environment, thereby protracting HIF-1 stability in the cytosol and subsequently favoring its translocation and activation [13, 14, 53, 54, 82, 111]