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Additionally, high-dose systemic administration may increase the risk of off-target effects

Rapidly increasing protein doses during phases of highly active inflammation and severe organ dysfunction may not confer net benefit and may even be associated with adverse outcomes in a subset of patients with concurrent acute kidney injury (22, 23)

[134] revealed that different immune cell populations within adipose tissue were associated with the aging- and obesity-induced IR in mice

Case presentation Case 1 : A 50-year-old Caucasian man with penile pain and double penile curvature of 5 (left ventrolateral), palpable nodule, and normal penile rigidity