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SKU: 73490890105
Price: 29.56 USD
Availability: InStock
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431 Cellular senescence is associated with a range of non-proliferative conditions, including lung fibrosis, kidney diseases, liver steatosis, metabolic syndrome related to obesity, type I and II diabetes, atherosclerosis, and neurodegenerative diseases such as Alzheimers and Parkinsons disease

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Mammalian target of rapamycin (mTOR), in particular, promotes cap-dependent translation of HIF-1 mRNA (79), while PI3K/AKT signaling dampens prolyl hydroxylase activity, reducing HIF-1 hydroxylation and preventing ubiquitin-mediated proteasomal degradation (80)