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There was a significant decrease in three main respiratory states: NADH (N)-linked OxPhos, NADH-succinate (NS)-linked OxPhos and NS-linked electron transfer system (ETS) (maximum uncoupled electron transfer capacity)

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Key sources: Ground flaxseed (great for both soluble and insoluble fiber) Chia seeds (form a gel that eases passage) Cooked vegetables like spinach, carrots, zucchini Low-sugar fruits like berries, kiwi, and pears Be cautious when adding fiber: Increase slowly over 7-10 days Always increase water intake alongside 3

Astaxanthin reduces the expression of FN, ICAM-1, and TGF-1 induced by HG to reduce ECM deposition, and significantly promotes the nuclear translocation and transcriptional activity of Nrf2, and induction the expression of HO-1 [149, 150]