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The pathogenesis of myelodysplastic syndrome (MDS) and erythropoiesis involve PLC-1/protein kinase C (PKC) signal transduction, especially nuclear PLC-1 gene (94).PLC-1a is a negative regulator of erythroid differentiation, and which is reduced in erythropoietin-responder MDS patients and in normal hematopoietic stem cell progenitors induced to erythroid differentiation (95)

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Detailed visualization of the ferroxidase center, threefold and fourfold channels, and mineral core has enhanced our understanding of iron entry, oxidation, and mineralization [121, 122]

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l-Citrulline Supplementation: Impact on Cardiometabolic Health

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The patient had no history of contact with toxic substances

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