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431,432 Some metabolic transcriptional factors (e.g., HIF-1a, NRF-1, and NRF-2) and nuclear receptors (e.g., estrogen receptor, retinoid X receptor, and peroxisome proliferator-activated receptors) have been identified to interact with PARP, affecting glucose and lipid metabolism and related metabolic syndromes

In the current samples, no difference was found in the two groups between these systems

Experimental studies demonstrate that acute high-altitude exposure alters gut microbial composition in rats, resulting in a 41.29% reduction in clopidogrel's area under the plasma concentration-time curve (AUC) and a 36.30% decrease in peak concentration (Cmax), with plasma clearance (CL) increasing 2.3-fold (Zhang et al., 2023)

J Evid Based Med Healthc

Data Availability Statement Not applicable.