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DOI: 10.1016/j.etap.2014.04.017 43

doi: 10.1007/s10517-016-3370-x

The procedure involves advancing a needle or catheter into the epidural or subarachnoid space between adjacent lumbar or sacral vertebral laminae, then injecting a corticosteroid, local anesthetic, or combination thereof

The lowest Phase 2 obesity arm was 1 mg weekly and produced 8.7% weight loss at 48 weeks, but the calculator starts below the trial dose to create a slower adaptation ladder