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The study revealed an association between the MTHFR polymorphism and central obesity, as well as increased androgenicity in these patients

Glutamine has a versatile role in cell metabolism, participating in tricarboxylic acid (TCA) cycle supplementation and the biosynthesis of nucleotides, glutathione (GSH), and other nonessential amino acids

Importantly, nuclear PKM2 also exhibits protein kinase activity to phosphorylate histone H3 at T11, which is essential for the dissociation of HDAC3 from the c-Myc promoter to initiate c-Myc transcription (Yang et al., 2014)

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