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Thinking through these factors transforms a simple question about location into a robust and well-designed research strategy

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2.13.1.5 V717I (London mutation) Position 717 in the amyloid precursor protein (APP) is a well-established hotspot for mutations linked to autosomal dominant Alzheimers disease (ADAD)

Amylin and hypertension: association of an amylin-G132A gene mutation and hypertension in humans and amylin-induced endothelium dysfunction in rats