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So again, we'll simplify because there's Hundreds to thousands of environmental toxins getting in daily in everyone's body

Modern strategies focus on precise modification of CRBN-binding scaffolds to enhance affinity and selectivity, high-throughput screening for POI-binding fragments that can induce favorable E3-POI interactions, and controlled induction of novel, specific interactions between E3 ligases and previously unrecognized substrates

doi: 10.1016/j.celrep.2012.07.003 64

Ramazzina, I., Berardinelli, A., Rizzi, F., Tappi, S., Ragni, L., Sacchetti, G., & Rocculi, P

Autologous cell extraction is limited in quantity and can cause additional trauma, while allogeneic cells may pose the risk of immune rejection [464]