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In our study, environmental inflammatory factors including IL-1 were significantly increased in mice subjected to social isolation stress, which is in line with previous studies that indicated that people who experience adversity early in their lives have a significant increase in CRP and IL-6 levels compared to healthy individuals 43

For a more functional assessment, markers like methylmalonic acid (MMA) can be helpful, as they rise when B12 is functionally deficient even if serum levels are borderline

This is one of the most common questions we hear, and it's a fair one

Bennett and Madden, 2014