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Collectively, this work proposes an LDH-based strategy that concurrently alleviates pathological acidosis, oxidative stress, mitochondrial dysfunction, and macrophage polarization imbalance, providing a potential nanotherapeutic approach for OA management

After reversal, Ppa-mce-1 mutant animals responded similar to wild type controls, indicating that Ppa -MCE-1 is not involved in the TEI of the predatory mouth form (Fig