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In accordance with the accumulation of lipid peroxides upon TCR stimulation, a significant decrease of GPX4, as assessed by Western blotting in various donors, was detected in subsequent weeks after stimulation (Fig

A further aspect, which needs to be taken into account, is the limited contact time achievable in vivo due to the reflex tear film turnover time, which has been reported to be ~50.0%/min in dogs and cats (115)

Of note, the anti-ferroptotic activity of FSP1 is strictly dependent on its affinity for NADPH

Fontana BD, Parker MO

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