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Several research groups [441, 536] reported that dual gRNA guided CRISPR/Cas9 system can significantly reduce the levels of HBV products

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The 3D kidney tissue allows for coculture of proximal tubule epithelial cells (PTECs) and glomerular microvascular endothelial cells (GMECs), which exhibit active reabsorption via tubular vascular exchange of solutes, similar to native kidney tissue [243] (Fig

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