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Interestingly, only small alterations in the levels of proteins associated with lysosomal processes were identified in CLN3 patient-derived cells compared to control (Supplementary Fig

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Figure 8 Finally, we confirmed that the use of iron chelators and ROS scavengers, such as thiourea, significantly reduced gentamicin-mediated mortality, which supports the hypothesis that the enhancement of the bactericidal action of gentamicin by cystine is mediated through the disruption of intracellular redox homeostasis

Lide, Ed., CRC Press, Inc., Boca Raton, FL Fujimura M, Usuki F, Sawada M, Takashima A (2009) Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain