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10.1016/j.cell.2010.02.024 110 Snchez-MartnP.KomatsuM

ER: Endoplasmic reticulum

Absorbed through the skin, intestinal and alveolar mucosa, Al enters the brain across the blood brain barrier (BBB), the choroid plexuses, and the nasal cavity and remains for a long time since its removal from the brain tissue is slow [5-8]

References 206 and 207 were the first to characterize a link between immunodeficiency and constitutive activation of PI3KAKT signalling, chronic hyperglycolytic metabolism and T cell exhaustion