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In Parkinsons disease models, riboflavin activates the Nrf2/HO-1 pathway, mitigating mitochondrial complex I-mediated ROS overproduction and safeguarding dopaminergic neurons (e.g., substantia nigra) (10, 64)

Methionine metabolism and phenotypic variability in X-linked adrenoleukodystrophy

This may be responsible for a reversal of IHC stimulation and powerful activity in the acoustic nerve off-phase of acoustic stimulation

Watson CJ, Whitledge JD, Siani AM, Burns MM

To date, a small handful of iron chelators have been approved by the FDA or have undergone clinical trials to treat iron overload-related diseases, transplantation, organ injury, and HCC