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A large molecule such as a peptide is primarily localized within the central compartment, and thus a small volume of distribution is expected

Adrian, S., Scherzinger, A., Sanyal, A., Lake, J., Falutz, J., Dub, M., Stanley, T., Grinspoon, S., Mamputu, C., Marsolais, C., Brown, T., & Erlandson, K

Downregulation of hypoxia-inducible factor-1alpha by RNA interference alleviates the development of collagen-induced arthritis in rats