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Indoxyl sulfate inhibits nitric oxide production and induces reactive oxygen species production, gradually damaging endothelial cell layer (Tumur and Niwa 2009)

2003 Apr;41(4 Suppl 4):S4-12

Moreover, peripheral pathology seen in CIPN can lead to maladaptive responses in the brain that contribute to CIPN even if chemotherapy drugs do not enter the brain, as we discuss below