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Combination therapy using PARP and ATR inhibitors has shown promising results in clinical trials, particularly in platinum-resistant HGSOC patients (127)

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Glutathione also helps to protect against DNA damage and is necessary for supporting the immune system and is required for replication of the Lymphocyte immune cells

34 It is important to note that the antioxidant properties of Mn are outcompeted by cellular iron binding to MnSOD, so iron may counteract the benefits of manganese antioxidants