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Common adverse effects include gastrointestinal symptoms (nausea, diarrhea, constipation), which typically improve with continued use

the STEP-1 trial reported approximately 14.9 percent on semaglutide over 68 weeks

However, clinical trials of arhalofenate have been conducted to assess its efficacy and safety in the treatment of gout and hyperuricemia

Proposed Mechanism of Action In theory, the vaccine works by: Delivering mRNA instructions encoding tumour-related antigens Presenting these antigens to immune cells Activating cytotoxic T-cells Directing immune attack toward cancer cells Despite these theoretical mechanisms, several key questions remain unanswered: Which tumour antigens are targeted Which cancer types are included Whether immune activation leads to real tumour shrinkage How long the immune response lasts What side effects may occur

J Med Chem 48(8):28382846 Ni S et al (2020) Recent progress in aptamer discoveries and modifications for therapeutic applications