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When B12 is deficient, then melanin is produced at a slow rate, hence the skin becomes spotted or patchy

Besides, the G2/M cell cycle arrest resulting from modulation of p27, Cyclin B1, and Cyclin E impairs growth and enhances cell death

doi: 10.1111/mmi.13073 116 SrivastavaS.BattuM

While CGRP is most known clinically as a target for migraine treatment (anti-CGRP antibodies are major migraine drugs), its role in bone metabolism is increasingly recognized