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Because multivalent IDR interactions often scale with length, we reasoned that converting R267 and R269 to glutamines (hereafter RRQQ) would eliminate DNA binding while minimally perturbing phase separation

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SOD3 is primarily found in tissues on the extracellular matrix and on cell surfaces

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However, these puncta were similar to those observed when expressing RNA binding deficient TDP-43

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Staying informed through reputable sources such as the NHS website, NICE (nice.org.uk), and the MHRA (gov.uk/mhra) is the safest approach as this rapidly evolving field continues to develop

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(NewYork, NY: Elsevier Science Publishers), 227287

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