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Even though, pharmacokinetic studies revealed that curcumin is found in quite lesser plasma concentration in human beings as compared to in vitro , yet many preclinical investigations have confirmed the anticancer activities of curcumin (Sharma et al., 2004)

These mechanisms support both functional repair and optimization of tissue architecture at a systemic level

The common allele is cytoprotective against the toxic effects of chemotherapeutics, whereas the functionally less competent allele is thought to increase the toxicity of anticancerogenic drugs in patients with this gene variant due to decreased metabolic activity of impaired enzyme

doi: 10.1016/j.fertnstert.2003.10.034 33 MicicSLalicNDjordjevicDBojanicNBogavac-StanojevicNBusettoGM

Biochemistry 52 , 105114 (2013)