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Proc Natl Acad Sci U S A (1993) 90:1005660.10.1073/pnas.90.21.10056 142 ParkSKChoMKParkH-KLeeKHLeeSJChoiSHet alMacrophage migration inhibitory factor homologs of Anisakis simplex suppress Th2 response in allergic airway inflammation model via CD4+CD25+Foxp3+ T cell recruitment

However, a large number of studies have been remaining at the cellular level to validate the target sites of these derivatives, while the studies of verifying their drug efficacy and conducting safety evaluations at the animal level are relatively scarce, which affects the potential for drug development

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The POA marker, developed in the 1960s, showed initial promise for detecting oncofetal antigens in serum but suffers from standardization issues and variability in sensitivity (6881%), limiting its usefulness in early diagnosis, particularly as it is often pathological in other hepato-biliary diseases [26, 27]