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Basic Research Projects of Liaoning Province (JYTMS20230073)

All authors read and agreed to the published version of the manuscript

51V NMR crystallography of vanadium chloroperoxidase and its directed evolution P395D/L241V/T343A mutant: protonation environments of the active site

In the National group only, there were 18 participants who completed the study but did not fill out the final evaluation forms despite several requests (7 cases in the placebo group, and 11 cases in the supplement group)

Olaparib, a PARP inhibitor (PARPi), has been demonstrated to not only exacerbate cellular senescence by amplifying DNA damage, upregulating senescence markers (e.g., SA--gal and p21), and inducing irreversible cell cycle arrest, particularly in replicatively senescent macrophages but also trigger mixed apoptotic and necrotic cell death at high doses