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Closed or near-closed epiphyses being a goal of approved use

PO: Extensively metabolized by the liver Plasma protein binding: 90% Peak 1-2 hr

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A drug can not generally have an oral bioavailability value higher than its value for f H , and oral bioavailability can equal f H only when all of the drug escapes from the GI tract and is able to enter the portal circulation (i.e