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MannII-mRFP was created by exchanging the BamHI/NotI sequence from MannII-BFP 63 with the equivalent sequence from pmRFP-N1 (Claudia Stuermer, University of Konstanz)

When a trigger reaches them, an enzyme called tyrosinase ramps up production and the result is a darker patch: sun spots, post-inflammatory marks after a spot or a scratch, or melasma