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Validation of carbon monoxide release role and chromatin modifying capability by CO-rich AuNPs Driven by the recognition that rapamycin significantly reduces the angiogenic activity of astrocytes when exposed to the CO donor CORM-2, a reduction attributed to the decreased protein level of HIF-1 induced by CORM-2 [69], we were compelled to develop further experiments to associate the pro-angiogenic effect in ECFC to the intracellular CO release of the COR-AuNPs

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Hossain F, Al-Khami AA, Wyczechowska D, et al

[49] [50] Liver damage is further characterized into hepatocellular (predominantly initial Alanine transferase elevation) and cholestatic (initial alkaline phosphatase rise) types

[26] to increase the cortisol level and increase cortisol clearance, he reported that there was an almost certain increased functional adrenal capacity to nearly double normal as evident from greater cortisol production per unit time