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Alpha-synuclein in parkinsons disease and other synucleinopathies: From overt neurodegeneration back to early synaptic dysfunction

doi: 10.1038/s41433-024-03015-2 225 SellersJTChrenekMAGirardotPENickersonJMPardueMTBoatrightJH

Recent meta-analysis indicates that the majority of studies (9 out of 11) report no significant circadian variation in total protein content while the few studies that do report variation may reflect false positive findings due to acrophase mismatch [3]

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Consequently, riboflavin may significantly enhance cell longevity by boosting the activity and concentration of antioxidant enzymes, such as superoxide dismutase, catalase, and glutathione peroxidase, that act on deactivating peroxides, which may create an oxidant environment (43)