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Studies have indicated that 47% of cirrhosis patients endure sleep disturbances, while 69% experience both disturbed sleep and depression

doi: 10.1016/j.celrep.2016.09.008 22 MacIverNJMichalekRDRathmellJC

Fluoroquinolone antibiotics can form zwitterion coordinated with Cu 2+ through the pyridone carbonyl oxygen and carboxylate oxygen, or anionic bidentate ligand coordinated through the pyridone carbonyl oxygen and carboxylate oxygen (Nedeljkovi et al

As a result, the excess free radicals begin to damage the bodys cells and tissues

By a variety of mechanisms, NO can react with different molecules, under ambient oxygen, and the derived products can damage the cellular macromolecules, such as lipids, DNA bases, proteins as well as thiols