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In human observational studies, both the AEDG peptide and its parent extract epithalamin were associated with significant telomere length increases in blood cells of subjects aged 6080, with a separate study documenting an 1119% increase in telomere length in subjects aged 6080 receiving the pineal peptide bioregulator (5)

In contrast, Ruminococcaceae UCG-009 was present in all experimental groups, and exhibited significantly greater relative abundance in both the LD control group and the 5A-1MQ-treated group switched from WD to LD compared to the WD control group (both significant before FDR correction

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