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doi: 10.1038/s41590-018-0276-y 2 BechtE.McinnesL.HealyJ.DutertreC

Opening and closing the loop may be required during substrate entry and product exit

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Observational studies have suggested associations between inadequate water intake and increased risk of NAFLD, though these relationships are complex and influenced by multiple confounding factors such as overall diet quality, physical activity levels, and consumption of sugar-sweetened beverages versus plain water

This finding has direct implications for research protocol design: most published and structured study designs incorporate a rest period following the active phase to allow receptor sensitivity to normalize before any subsequent research cycle, rather than using continuous, uninterrupted administration