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Emerging evidence revealed that vitamin C at pharmacological doses potentiates the formation of O 2 and H 2 O 2 that disrupt intrinsic iron metabolism and selectively sensitize GBM cells to chemotherapy (Fig

In a single-center, randomized, double-blind, placebo-controlled trial conducted at the Emergency Department of a hospital in Brazil, 140 patients with severe COVID-19 infection and oxyhemoglobin saturation of less than 94% or respiratory rate higher than 24 breaths/minute were randomized to receive N-acetylcysteine 21,000 mg (approximately 300 mg/kg) for 20 hours or dextrose 5% (placebo)

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