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However, mAb treatment tended to oppose age-related changes in 30 of these metabolites (22 marginally significant after FDR correction), including a reduction in the age-related rise of many glycerophospholipids, and a distinct clustering of metabolites from heart tissue in Old Con versus Old mAb-treated animals by PCA (Supplementary Fig

J Lipid Res 54(9):23252340 Dhurjad P, Dhavaliker C, Gupta K, Sonti R (2022) Exploring drug metabolism by the gut microbiota: modes of metabolism and experimental approaches

Surprisingly, only astaxanthin synthase and geranyl pyrophosphate synthase in astaxanthin synthesis pathway were identified as the upregulated DEGs with the other genes not significantly changed, indicating that MT regulate the global-cell metabolic network which was not only the single astaxanthin synthesis pathway to improve astaxanthin production