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Tacrolimus is a powerful immunosuppressant commonly prescribed to prevent organ transplant rejection

Rodriguez-Farre and R

When this organ faces malfunction or disease, the implications can be far-reaching, affecting numerous bodily processes

In PKD1-deficient cells, 4-HNE, as a signaling molecule, promotes cell proliferation and aggravates cyst growth by activating AKT, S6, STAT3, and RB (Fig