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In preclinical studies, vitamin C monotherapy at millimolar doses exhibits cytotoxic effects on neuroblastoma, glioma, and GBM cells [80,81,82]

doi: 10.1016/j.isci.2022.103881 156 StineZEWaltonZEAltmanBJHsiehALDangCV

B.Glutamine metabolism involves GSH biosynthesis GSH is a widely present tripeptide composed of glutamate, glycine, and cysteine, with substrate availability determining the rate of GSH biosynthesis in cells