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While OTC medications may help relieve pain and soreness, mixing nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, with alcohol could increase the risk of stomach bleeding or ulcers

However, comprehensive long-term human safety data does not exist

Yao M, Tabuchi H, Nagashima Y, Baba M, Nakaigawa N, Ishiguro H, Hamada K, Inayama Y, Kishida T, Hattori K (2005) Gene expression analysis of renal carcinoma: adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma

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Pregnancy: Hormonal changes and increased pressure on muscles during pregnancy can cause frequent muscle spasms, especially in the legs