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An imbalanced oxidative status due to the production of ROS can be reduced by the presence of antioxidants such as PtNPs [86]

According to Chengs study, synovial macrophages release Semaphorin 5 A activating PI3K/AKT/mTOR signaling, thereby effectively preventing the occurrence of ferroptosis [148]

demonstrated that Nos2-derived NO modulated the pathogenic IL-1 secretion from the local macrophages, which acted to downstream target innate lymphoid cell 3 (ILC3), resulting in the up-regulation of IL-17 A to trigger and accelerate the development of MIP [67]