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doi: 10.1016/j.brainres.2018.03.015 292 SugitaH.MiyajimaC.DeguchiY

Stereoselective conjugation of prostaglandin A2 and prostaglandin J2 with glutathione, catalyzed by the human glutathione S-transferases A1-1, A2-2, M1a-1a, and P1-1

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39,40,41,42 This process requires an active escort mechanism, whereby the AAA+ ATPase p97/valosin-containing protein (VCP) (known as Cdc48 in yeasts) extracts misfolded, damaged, or improperly synthesized proteins from the ER to enable their recognition and processing by ER-dedicated E3 ubiquitin ligases, which mark them for degradation by the 26S proteasome

The recoveries of GSH with different concentrations ranged from 93.76 to 108.50% and the relative standard deviation from 0.30 to 5.96%