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The discovery that NNMT expression is dramatically elevated in adipose tissue of obese humans and animal models, and that NNMT inhibition or knockdown prevents diet-induced obesity and improves metabolic health, has catalyzed intense research interest in NNMT as a therapeutic target for obesity, metabolic syndrome, and related conditions

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Firstly, the concept of metabolic syndrome and its different definitions will be reviewed, together with the symptoms or risk factors associated

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intact GH Notes for Investigators: Studied for adipose-tissue signaling without broad GHIGF axis activation