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FDA labeling advises renal-function monitoring when adverse reactions could lead to volume depletion, especially during treatment initiation or dose escalation

These are exposure biomarkers showing the chemical exposure and biologically active dosage, effect biomarkers containing information on structural and functional changes such as firstly-observed clinical symptoms and genotoxins causing DNA damage, individual sensitivity biomarkers responsible of enzymes affecting cancer

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Further correlations between gut microbiota and DN phenotypes are detailed in Table 2