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Their further synthesis is disrupted and cannot occur regularly, resulting in symptoms such as frequent breakdowns, spontaneous bruising, weakness, and nighttime fever

While one upregulates growth hormone receptors and accelerates angiogenesis at the immediate site of damage, the other acts systemically to mediate actin polymerization

A vial that moves from freezer to room temperature and back again over and over may collect condensation risk and experience more stress than a vial that stays in one stable cold environment

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If subclinical vitamin B12 is suspected, then circulating total vitamin B12 or transcobalamin (TC)-bound B12 (i.e., holo TC) in serum should be measured first, followed by methylmalonic acid (MMA) or homocysteine in serum, both more sensitive functional biomarkers that reflect B12 stores rather than intake