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For some heavy metals (Cd, Hg), for which carcinogenic role is known, there are no specific exposure levels that indicate toxicity, as toxicity is not related only to environmental concentrations, but depends on other mechanisms also that have not yet been taken into consideration (30, 55)

Epilepsia Open 7:504511

Figure 2 3.4 Meta-analysis of the effects of exercise combined with tDCS on cognitive function in older adults This study incorporated data from 10 randomized controlled trials (RCTs), encompassing 19 distinct study outcomes and 1,769 participants, to evaluate the efficacy of combined exercise and tDCS interventions on cognitive function in older adults (Figure 3)

When compared to conventional pharmaceutical therapies, these investigations highlight the therapeutic equivalency or synergistic impact of specific nutraceuticals

Several scientific questions remain open