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Can Vitamin B12 Trigger Acne

It is likely that the larger number of statistically significant changes to the microbiome observed in the groups switched from WD to LD reflects their more numerous exposures to different diets, longitudinal changes in dietary exposure, the stress associated with diet switch, the negative energy state achieved by treatment and/or diet-driven weight loss, or a combination of these factors, but it may also be related to differences in terminal body weight and fat mass since both adiposity and diet composition have been shown to modulate the mouse gut microbiome profile

Prim Care Companion J Clin Psychiatry 2007

Additionally, standard injection risks (infection at injection site, vein irritation for IV, etc.) apply, though proper sterile technique makes these complications uncommon

Take a shower before to heat up your body a bit and remove any external toxins