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Today 53, 240-253 (2018)

Coffee melanoidins are able to chelate transition metal ions, that is they are able to bind Zn2+, Cu2+, and Fe2+ (Takenaka, 2005

Moreover, in a meta-analysis that included five studies focusing on type 2 diabetic patients, the alanine-encoding allele was associated with a reduced risk of macroalbuminuria (CR 0.65, 95% CI 0.520.80) compared with the valine-encoding allele (Tian et al., 2011)